منابع مشابه
RNA Repair: Damage Control
RNA in a cell is subject to many of the same insults as DNA. RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress.
متن کاملDNA damage, repair and mutations
DNA damage, repair and mutations Harry Vrieling Introduction DNA contains the blueprint for the proper development, functioning and reproduction of organisms ranging from bacteria, low eukaryotes to vertebrates like man. It is therefore of extreme importance that both replication, i.e. the duplication of DNA, and the segregation of fully replicated DNA molecules (i.e. the chromosomes) over the ...
متن کاملDNA Damage, Repair, and Diseases
DNA is the essential carrier of genetic information in all living cells. How is the huge amount of DNA in organisms from bacteria to humans maintained and protected from the ravages of noxious agents in the environment? The chemical stability of the DNA molecule is not unusually great, DNA undergoes several types of spontaneous modifications, and it can also react with many physical and chemica...
متن کاملRNA Repair: Damage Control Dispatch
Damage to DNA is a significant issue for all cells, particularly in cancer where DNA repair commonly fails. It is not widely appreciated that many agents that cause damage to DNA, such as radiation and certain cancer chemotherapy drugs, also damage RNA. Given that there is at least as much RNA in a cell as DNA, wherever DNA is damaged by such agents, RNA is surely damaged as well. When the dama...
متن کاملCardiac Damage and Its Repair
InDrosophila, the Hippo-signaling pathway is awell-known orchestrator of organismal size. Probing whether these mechanisms also mould organogenesis in mammals, James Martin and colleagues disrupted multiple Hippo pathway components in the developing mouse heart. These targets for conditional knockout include the MST kinases (the mammalian Hippo homologues), Salvador (a scaffold protein that bin...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2009
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro2264